There have been three discoveries that are the most significant for Deutenomics and have positioned it in translational medicine.
In the first paper Dr. Gábor Somlyai established the fundamental role of deuterium depletion as a regulator of cell proliferation.
Somlyai G., et al. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Letters. 1993 Feb 8; 317(1-2):1-4. doi: 10.1016/0014-5793(93)81479-j
The second paper, by Dr. Abdullah Olgun, pinpointed the cellular mechanism of how deuterium interferes with energy production of ATP synthesis.
Olgun A. Biological effects of deuteronation: ATP synthase as an example. Theor Biol Med Model. 2007 Feb 22;4:9. doi: 10.1186/1742-4682-4-9
The third paper connected the role of deuterium in metabolic water production in the medical setting, meaning Dr. László Boros identified the exact processes by which we deuplete (deplete deuterium) in these innate biochemical physiological specific reactions in glycolysis, the TCA cycle, peroxisomes etc.
Boros L.G., et al. Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Med Hypotheses. 2016 Feb;87:69-74. doi: 10.1016/j.mehy.2015.11.016