SIGNIFICANT FINDINGS
There have been four discoveries that are the most significant for Deutenomics and have positioned it in translational medicine.
In the first paper Dr. Gábor Somlyai established the fundamental role of deuterium depletion as a regulator of cell proliferation.
Somlyai G., et al. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Letters. 1993 Feb 8; 317(1-2):1-4. doi: 10.1016/0014-5793(93)81479-j
The second paper, by Dr. Abdullah Olgun, pinpointed the cellular mechanism of how deuterium interferes with energy production of ATP synthesis.
Olgun A. Biological effects of deuteronation: ATP synthase as an example. Theor Biol Med Model. 2007 Feb 22;4:9. doi: 10.1186/1742-4682-4-9
The third paper connected the role of deuterium in metabolic water production in the medical setting, meaning Dr. László Boros identified the exact processes by which we deuplete (deplete deuterium) in these innate biochemical physiological specific reactions in glycolysis, the TCA cycle, peroxisomes etc.
Boros L.G., et al. Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Med Hypotheses. 2016 Feb;87:69-74. doi: 10.1016/j.mehy.2015.11.016
The fourth paper by Roman A. Zubarev et al. unexpectedly found deuterium levels well beyond the natural abundance of deuterum in the enviroment, in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. The mechanism by which specific amino acids and tissues are enriched remains to be clarified.
Gharibi H, Chernobrovkin AL, Eriksson G, Saei AA, Timmons Z, Kitchener AC, Kalthoff DC, Lidén K, Makarov AA, Zubarev RA. Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass. J Am Chem Soc. 2022 Feb 16;144(6):2484-2487. doi: 10.1021/jacs.1c12512. Epub 2022 Feb 2. PMID: 35107291; PMCID: PMC8855419.