Deutenomics is an interdisciplinary approach to medical biochemistry as it incorporates sub molecular isotope effects known about deuterium into clinical reasoning. It is rapidly evolving science with trajectories into diagnostics, prevention, as well as medical interventions.

The term Deutenomics was coined by Dr. László G. Boros and first introduced at the 4th International Congress on Deuterium Depletion, Budapest in 2019 during his presentation entitled Metabolic protonation of matrix water entails deuterium depletion for mitochondrial health via Eigen and Zundel type hydronium complex formation: medical implications and is explained very well in this short and concise interview.

In 2016 he published the ground breaking paper that described the precise mechanism by which our bodies prevent deuterium from entering the mitochondria.

The English suffix -nomics is derived from the Greek νόμος nomos, meaning "law." The fields ending with -(n)omics thus mean "law of" in this case everything that involves heavy hydrogen, deuterium.

Hydrogen, the smallest element on the periodic table, contains a single positively charged proton and an electron. Nobel Laureate Albert Szent-Györgyi stated that life is about recycling protons, the more effectively they move, the more efficient our bodies function.

Deutenomics is based on the foundational concept that describes how water moves in our bodies to carry either hydrogen or deuterium. Water consists of two hydrogen atoms and one oxygen atom (H2O), semi heavy (HDO) and heavy water (D2O) carry a deuterium atom instead of hydrogen.

Deuterium is a stable isotope of hydrogen. An isotope is a different form of the element with the same atomic number (protons) but with different atomic mass (neutrons) and properties. In addition to a proton, the deuterium atom contains a neutron, making it twice as heavy and the nucleus twice the size of that in a hydrogen atom. This is the largest difference in isotope chemistry and biology as it doubles the weight by 100%.

Deuterium is present in all water at varying concentrations which have steadily increased over time. On average, most drinking water contains ~150 deuterium atoms per 1 million hydrogen atoms or 150 parts per million (ppm).

Up to 70% of the human body consists of water. The deuterium content in this water is ~0.015%. In quantitative content (atomic percents), it takes 12th place among chemical elements that compose human bodies. In this respect, deuterium may be classified as a microelement among which it takes the first place as the content of such microelements as copper, iron, zinc, molybdenum or manganese in the organism is tenfold and hundredfold less than that of deuterium.

If we compare this to other elements found in the body, it is quite significant:

At approx. 12-14 mmol/L deuterium is present in the bloodstream 2 to 4 times as much as glucose, 3 times as much as potassium, 5 times as much as calcium and there is 10 to 18 times more deuterium as there is magnesium in the blood.

If the average concentration of deuterium in our body fluids exceeds healthy (<125 ppm) levels, mitochondrial dysfunction is the result. Mitochondrial dysfunction is at the root of 80% to 95% of all chronic diseases we see today including immune system dysfunction, diabetes, cancer, obesity, neurocognitive decline, cardiovascular disease and autoimmune processes.

The main principles of medical deutenomics are:

  • Life is a proton driven large set of organic chemical bond reducing metabolic reactions for energy production and structure formation that are compromised by heavy hydrogen deuterium.
  • The accumulation of deuterium from nutrients is an important disease-causing factor.
  • Deuterium regulation may well be the most important preventive and therapeutic medical intervention using naturally deupleted hydrocarbon (fat) diets combined with deupleted water consumption.
  • Accordingly, diets may exert therapeutic effects if the amount of deuterium entering the body is reduced via naturally deupleted metabolic and nutritional ketosis, which is the physiological biochemistry profile of humans at birth and morning awakenings.


Petra Davelaar Dorfsman

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