BIOLOGICAL EFFECTS OF DEUTERIUM DEPLETED WATER
The biological Impact of deuterium and the therapeutic potential of deuterium depleted water
A very comprehensive review paper published on July 22, 2024 provides and excellent summary of the research, so far.
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The authors state that deuterium is indispensable for maintaining normal cellular function while its enrichment and depletion can affect living systems at multiple levels, including but not limited to molecules, organelles, cells, organs, and organisms.
The tolerance of living systems to deuterium exhibits species specificity. Generally, the lower the evolutionary organization level of an organism is, the easier it is to adapt to the existence of deuterium in the culture medium.
The normal D/H ratio in water plays a crucial role in ensuring the passage and kinetics of many biochemical reactions and regulating the energy metabolism and functional activity of mitochondria, and thus it is of great significance in maintaining the normal growth of living systems.
Effects of deuterium excess:
The extensive replacement of hydrogen by deuterium has resulted in several negative effects on living systems, including but not limited to:
1. Disrupting cell division mechanisms, impairing cell cycle progression, inhibiting cell differentiation, and slowing cellular metabolism and growth
2. Reducing protein and nucleic acid synthesis, as well as affecting the structure of DNA
3. Altering the kinetics rates and conformation of enzymes, thereby affecting their activity and depressing tissue metabolism
4. Increasing the mutation frequencies of certain bacteriophages and bacteria (
5. Causing organ damage, affecting the reproductive potential and shortening the lifespan of animals
It was reported that deuterium at concentrations higher than natural levels (100- to 1000-fold) has significant, mainly toxic, effects. The excessive D not only inhibit cell growth and division by affecting microscopic kinetics but also increase protein rigidity, slow down ATP production, influence gene expression, fatty acid composition, and hydration of membrane lipids, as well as impact the function of Ca2+ and Cl− channels through osmotic-like stress.
Deuterium-enriched water with D concentrations up to 99% almost completely inhibited mitochondrial respiratory chain reactions. Excessive deuterium also negatively impacts cellular metabolism, leading to physiological, morphological, and cytological alterations in cells including but not limited to decreased cell proliferation and metabolic activity, inhibited cell cycle, prolonged cell doubling time, and altered cell morphology.
Effects of deupletion:
Deuterium depleted water (DDW) possess various special effects, including but not limited to altering cellular metabolism and potentially inhibiting the growth of cancer cells, demonstrating anxiolytic-like behavior, enhancing long-term memory in rats, reducing free radical oxidation, regulating lipid metabolism, harmonizing indices related to diabetes and metabolic syndrome, and alleviating toxic effects caused by cadmium, manganese, and other harmful substances, implying its tremendous potential in anticancer, neuroprotective, antiaging, antioxidant, obesity alleviation, diabetes and metabolic syndrome treatment, anti-inflammatory, and detoxification.
At the organ level, reducing the deuterium concentration in the body significantly affect the secretion activities of the thyroid and pituitary glands, thereby influencing the endocrine patterns.
Research indicated that not only a rapid decrease in deuterium content in the body resulting from the consumption of DDW can affect the function of the pituitary-thyroid gland axis but also a gradual decrease in body deuterium content can impact the function of the entire hypothalamic-pituitary-thyroid axis.
Qu J, Xu Y, Zhao S, Xiong L, Jing J, Lui S, Huang J and Shi H (2024) The biological impact of deuterium and therapeutic potential of deuterium-depleted water. Front. Pharmacol. 15:1431204. doi: 10.3389/fphar.2024.1431204
The biological Impact of deuterium and the therapeutic potential of deuterium depleted water
A very comprehensive review paper published on July 22, 2024 provides and excellent summary of the research, so far.
The authors state that deuterium is indispensable for maintaining normal cellular function while its enrichment and depletion can affect living systems at multiple levels, including but not limited to molecules, organelles, cells, organs, and organisms.
The tolerance of living systems to deuterium exhibits species specificity. Generally, the lower the evolutionary organization level of an organism is, the easier it is to adapt to the existence of deuterium in the culture medium.
The normal D/H ratio in water plays a crucial role in ensuring the passage and kinetics of many biochemical reactions and regulating the energy metabolism and functional activity of mitochondria, and thus it is of great significance in maintaining the normal growth of living systems.
Effects of deuterium excess:
The extensive replacement of hydrogen by deuterium has resulted in several negative effects on living systems, including but not limited to:
1. Disrupting cell division mechanisms, impairing cell cycle progression, inhibiting cell differentiation, and slowing cellular metabolism and growth
2. Reducing protein and nucleic acid synthesis, as well as affecting the structure of DNA
3. Altering the kinetics rates and conformation of enzymes, thereby affecting their activity and depressing tissue metabolism
4. Increasing the mutation frequencies of certain bacteriophages and bacteria (
5. Causing organ damage, affecting the reproductive potential and shortening the lifespan of animals
It was reported that deuterium at concentrations higher than natural levels (100- to 1000-fold) has significant, mainly toxic, effects. The excessive D not only inhibit cell growth and division by affecting microscopic kinetics but also increase protein rigidity, slow down ATP production, influence gene expression, fatty acid composition, and hydration of membrane lipids, as well as impact the function of Ca2+ and Cl− channels through osmotic-like stress.
Deuterium-enriched water with D concentrations up to 99% almost completely inhibited mitochondrial respiratory chain reactions. Excessive deuterium also negatively impacts cellular metabolism, leading to physiological, morphological, and cytological alterations in cells including but not limited to decreased cell proliferation and metabolic activity, inhibited cell cycle, prolonged cell doubling time, and altered cell morphology.
Effects of deupletion:
Deuterium depleted water (DDW) possess various special effects, including but not limited to altering cellular metabolism and potentially inhibiting the growth of cancer cells, demonstrating anxiolytic-like behavior, enhancing long-term memory in rats, reducing free radical oxidation, regulating lipid metabolism, harmonizing indices related to diabetes and metabolic syndrome, and alleviating toxic effects caused by cadmium, manganese, and other harmful substances, implying its tremendous potential in anticancer, neuroprotective, antiaging, antioxidant, obesity alleviation, diabetes and metabolic syndrome treatment, anti-inflammatory, and detoxification.
At the organ level, reducing the deuterium concentration in the body significantly affect the secretion activities of the thyroid and pituitary glands, thereby influencing the endocrine patterns.
Research indicated that not only a rapid decrease in deuterium content in the body resulting from the consumption of DDW can affect the function of the pituitary-thyroid gland axis but also a gradual decrease in body deuterium content can impact the function of the entire hypothalamic-pituitary-thyroid axis.
Qu J, Xu Y, Zhao S, Xiong L, Jing J, Lui S, Huang J and Shi H (2024) The biological impact of deuterium and therapeutic potential of deuterium-depleted water. Front. Pharmacol. 15:1431204. doi: 10.3389/fphar.2024.1431204