There are two mechanisms by which deuterium changes the expression of genes.
When deuterium populates the deoxyribose sugar backbone moiety that forms the double helix in DNA, there are conformational changes that frame shift the expression of genetic material without small nuclear polymorphism (SNPs) or epigenetic events. Excess deuterium can cause major genomic transformation in living organisms. This deserves the question whether SNPs and mutations are merely symptoms of weakening cellular energetics which is now referred to as “Epigenetics”?
If DNA accumulates in the nucleus and is larger than it would be if there was less deuterium present, the size of the nucleus increases, aneuploidy develops, which overreaches cell cycle thresholds to maintain uniformly active cell division processes. This is why we call deuterium an oncoisotope.