METABOLIC CROWDING
High levels of deuterium causes metabolic crowding as important metabolic biological thresholds are affected, namely proton/hydrogen harvesting and water recycling from the hydratases in the TCA cycle. Protons are no longer able to deliver electrons to Complex I. Protons can no longer get into the mitochondrial matrix and hydrogens pile up outside of mitochondria, citrate can no longer synthesize deuterium-depleted fatty acids, carbon dioxide piles up, organic acids pile up and start branching, and lactic acids also accumulate. This is why pyruvate converts to lactic acid, even in the presence of oxygen. All of this creates an acidic environment. This is what we call metabolic crowding. This is the Warburg effect.